Mediastinal masses in children comprise a heterogeneous group of malignant and benign neoplasms. The majority of malignant tumors of mediastinum are Hodgkins and non-Hodgkins lymphomas, germ cell tumors, and neuroblastomas. Thymic tumors account for 1.5% of mediastinal masses in children [1]. Thymomas, thymic carcinoids, and thymic carcinomas constitute thymic epithelial neoplasms (TEN). Carcin...

Thymomas and thymic carcinomas are rare mediastinal neoplasms arising from epithelial cells, the presence of synchronous or metachronous primary in a single patient is an extremely event. Thymoma patients appear to have inherent predisposition toward developing additional neoplasms. This additionally presents diagnostic challenge, revealing importance multidisciplinary expertise management thes...

The diagnosis of thymic epithelial neoplasms is normally rendered after careful evaluation of their histologic features. In some cases, however, the morphological heterogeneity or overlap with neoplasms of other organ systems can lead to diagnostic uncertainty. On the basis of this, the use of immunohistochemical stains as a diagnostic adjunct has become a popular tool. Although undoubtedly, im...

Thymic epithelial neoplasms are commonly aetiology of the anterior mediastinum masses in adults. It represents 20–30% of all mediastinal tumours in adults. Ectopic thymomas usually affect the neck, mediastinal compartments, lung, and pleura, arising from aberrant thymic tissue. For giant thymoma, there is still no consensus on the surgical approach.  We herein report a patient with a giant thym...

The classification of thymic epithelial neoplasms has been one of the most controversial issues in tumor pathology. There are two opposing schools of pathologists holding different views regarding the classification of thymic epithelial neoplasms. One school of pathologists believe that histological classification of thymomas is not possible or useful. Another school of pathologists believe tha...

Objective: There have been con ̄icts concerning the criteria for diagnosing malignant epithelial neoplasms of thymic origin. To differentiate thymic carcinomas from thymomas, the maturation stage of T-lineage lymphoid cells in®ltrating thymomas and thymic carcinomas was examined by ̄ow cytometry to associate it with the degree of tumor malignancy. Methods: Multidimensional ̄ow cytometric analysi...

Thymic epithelial tumors (TETs) comprise a heterogeneous group of epithelial-derived thymic neoplasms with diverse clinical behavior and underlying molecular genetic features. Owing to their rare nature, the classification TETs has only recently begun be fully explored. The advent advanced studies, particularly ability sequence DNA RNA in massively parallel fashion, led an increased understandi...

The updated, recently published 2021 WHO classification of thymic tumors incorporates the most recent advances in field pathology, with particular emphasis on primary epithelial neoplasms. This new edition retains basic format previous editions for neoplasms reaffirming schema originally proposed first edition, which utilized a combination letters and numbers designation these tumors. Only mini...